Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche.

ABSTRACT: The ability of breast cancer cells to interconvert between epithelial and mesenchymal states contributes to their metastatic potential. As opposed to cell autonomous effects, the impact of epithelial-mesenchymal plasticity (EMP) on primary and metastatic tumor microenvironments remains poorly characterized. Herein we utilize global gene expression analyses to characterize a metastatic model of EMP as compared to their non-metastatic counterparts. Using this approach, we demonstrate that upregulation of the extracellular matrix crosslinking enzyme tissue transglutaminase-2 (TG2) is part of a novel gene signature that only emerges in metastatic cells that have undergone induction and reversion of epithelial-mesenchymal transition (EMT). Consistent with our model system, patient survival is d

SUBMITTER: Shinde A 

PROVIDER: S-EPMC7018754 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature