The Use of Computer Simulation Modeling to Estimate Complications in Patients with Type 2 Diabetes Mellitus: Comparative Validation of the Cornerstone Diabetes Simulation Model.

ABSTRACT:

Objective

The objective of this study was to assess the validity of the Cornerstone Diabetes Simulation (CDS), a Microsoft Excel^®-based patient-level simulation for type 2 diabetes mellitus based on risk equations from the revised United Kingdom Prospective Diabetes Study Outcomes Model (UKPDS-OM2, also known as UKPDS 82).

Methods

Three levels of validation were conducted. Internal validation was assessed through independent review and model stress-testing. External validation was addressed by populating the CDS with baseline characteristics and treatment effects from three major diabetes clinical trials used in the Fifth Mount Hood Diabetes Challenge (MH5) for computer simulation models. Cross-validation of predicted outcomes was tested versus eight models that p

SUBMITTER: Su ZT 

PROVIDER: S-EPMC7018921 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature