Risk Factors for Severe Opioid-Related Adverse Events in a National Cohort of Medical Hospitalizations.

ABSTRACT:

Background

Opioids are a leading cause of adverse drug events in the hospital. Guidelines recommend that physicians assess the risks of opioids and discuss them with patients when considering opioid use. There are no studies examining patient- and prescribing-related risk factors for opioid-related adverse drug events (ORADEs) in hospitalized medical patients.

Objective

To identify independent risk factors for severe ORADEs in hospitalized medical patients.

Design

Retrospective cohort study.

Patients

Medical patients hospitalized at US, non-federal, and acute care facilities, with at least one pharmacy charge for an opioid during hospitalization. We excluded patients with metastatic malignancy, hospice, or palliative care billing codes.

Main measures

We

SUBMITTER: Herzig SJ 

PROVIDER: S-EPMC7018928 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature