Connexin43 expression in bone marrow derived cells contributes to the electrophysiological properties of cardiac scar tissue.

ABSTRACT: Cardiac pathologies associated with arrhythmic activity are often accompanied by inflammation. The contribution of inflammatory cells to the electrophysiological properties of injured myocardium is unknown. Myocardial scar cell types and intercellular contacts were analyzed using a three-dimensional reconstruction from serial blockface scanning electron microscopy data. Three distinct cell populations were identified: inflammatory, fibroblastic and endocardial cells. While individual fibroblastic cells interface with a greater number of cells, inflammatory cells have the largest contact area suggesting a role in establishing intercellular electrical connections in scar tissue. Optical mapping was used to study the electrophysiological properties of scars in fetal liver chimeric mice genera

SUBMITTER: Vasquez C 

PROVIDER: S-EPMC7018966 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature