Directional Stepping Model for Yeast Dynein: Longitudinal- and Side-Step Distributions.

ABSTRACT: Motor proteins are biological machines that convert chemical energy stored in ATP to mechanical work. Kinesin and dynein are microtubule (MT)-associated motor proteins that, among other functions, facilitate intracellular transport. Here, we focus on dynein motility. We deduce the directional step distribution of yeast dynein motor protein on the MT surface by combing intrinsic features of the dynein and MTs. These include the probability distribution of the separation vector between the two microtubule-binding domains, the angular probability distribution of a single microtubule-binding domain translation, the existence of an MT seam defect, MT-binding sites, and theoretical extension that accounts for a load force on the motor. Our predictions are in excellent accord with the measured lo

SUBMITTER: Fayer I 

PROVIDER: S-EPMC7018985 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature