Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation.

ABSTRACT: Cancer chemotherapy induces sarcopenia, which is a rapid loss of muscle mass that directly restricts daily activities and leads to poor quality of life and increased mortality. Although hormone-related therapies have been used to improve appetite and nutritional status, current treatments are considered palliative. Thus, the protection of skeletal muscle loss without adverse effects is essential to allow the maintenance of chemotherapy in cancer patients. Magnolol from Magnolia officinalis has several pharmacological effects including anti-cancer and anti-inflammatory activities, but the protection from muscle atrophy is not well-understood. In the present study, we investigated the effects of magnolol on muscle wasting and macrophage subtypes in a cisplatin-induced sarcopenia mouse

SUBMITTER: Lee C 

PROVIDER: S-EPMC7018987 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature