Geometric Control of Frequency Modulation of cAMP Oscillations due to Calcium in Dendritic Spines.

ABSTRACT: The spatiotemporal regulation of cyclic adenosine monophosphate (cAMP) and its dynamic interactions with other second messengers such as calcium are critical features of signaling specificity required for neuronal development and connectivity. cAMP is known to contribute to long-term potentiation and memory formation by controlling the formation and regulation of dendritic spines. Despite the recent advances in biosensing techniques for monitoring spatiotemporal cAMP dynamics, the underlying molecular mechanisms that attribute to the subcellular modulation of cAMP remain unknown. In this work, we model the spatiotemporal dynamics of calcium-induced cAMP signaling pathway in dendritic spines. Using a three-dimensional reaction-diffusion model, we investigate the effect of different spatial

SUBMITTER: Ohadi D 

PROVIDER: S-EPMC7018999 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature