A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer.

ABSTRACT:

Background

Epidemiologic data are inconsistent regarding the vitamin E-lung cancer association, and no study to our knowledge has examined serologic changes in vitamin E status in relation to subsequent risk.

Methods

In a cohort of 22 781 male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, we ascertained 3184 lung cancer cases during up to 28 years of observation. Cox proportional hazards models examined whether higher serum alpha-tocopherol concentrations at baseline, 3 years, or the interval change were associated with lower lung cancer risk. All statistical tests were two-sided.

Results

After adjustment for age, body mass index, smoking intensity and duration, serum total cholesterol, and trial intervention group, we found lower lung cancer

SUBMITTER: Huang J 

PROVIDER: S-EPMC7019088 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature