Mussel-inspired conductive Ti₂C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction.

ABSTRACT: Rationale: Researches on conductive engineering cardiac patch (ECP) for myocardial infarction (MI) treatment have achieved some progress in the animal while the availability of traditional conductive materials in ECP is still limited because of their controversial cytotoxicity. Here we aim to introduce a novel hydrophilic biocompatible conductive material: MXene Ti₂C and mussel-inspired dopamine into PEGDA-GelMA cryogel to construct a bio-functional ECP of which the property closes to natural heart for the repair of MI. Method: MXene Ti₂C was etched from MAX Ti₂AlC, then uniformly dispersed into the prepolymer composed with dopamine-N', N'-methylene-bisacrylamide, methacrylate-gelatin, and poly (ethylene glycol) diacrylate by simple water bath

SUBMITTER: Ye G 

PROVIDER: S-EPMC7019164 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature