Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.

ABSTRACT: Rationale: Cancer phosphoproteomics can provide insights regarding kinases that can be targeted for therapeutic applications. Monitoring the phosphoproteomics in cancer is expected to play a key role in optimizing treatments with kinase inhibitors. Clinical phosphoproteomics in surgical tissues and patient-derived models has been studied intensively. However, the reported data may not accurately reflect the phosphosignaling status in patients due to the effect of ischemia occurring during surgery or changes in the characteristics of cancer cells when establishing the models. In contrast, endoscopic biopsies have an advantage for clinical phosphoproteomics because they can be rapidly cryo-preserved. We aimed to develop a highly sensitive method for phosphoproteomics in endoscopic bio

SUBMITTER: Abe Y 

PROVIDER: S-EPMC7019165 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature