Self-activated in vivo therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes.

ABSTRACT: Biomineralization of enzymes for in vivo diagnosis and treatment of diseases remain a considerable challenge, due to their severe reaction conditions and complicated physiological environment. Herein, we reported a biomimetic enzyme cascade delivery nanosystem, tumor-targeted erythrocyte membrane (EM)-cloaked iron-mineralized glucose oxidases (GOx-Fe⁰@EM-A) for enhancing anticancer efficacy by self-activated in vivo cascade to generate sufficient high toxic •OH at tumor site. Methods: An ultra-small Fe⁰ nanoparticle (Fe⁰NP) was anchored in the inner cavity of glucose oxidase (GOx) to form iron-mineralized glucose oxidase (GOx-Fe⁰) as a potential tumor therapeutic nanocatalyst. Moreover, erythrocyte membrane cloaking delivery

SUBMITTER: Liu W 

PROVIDER: S-EPMC7019169 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature