⁶⁸Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study.

ABSTRACT: Rationale: Treatment options for recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC) and salivary duct carcinoma (SDC), major subtypes of salivary gland cancer, are limited. Both tumors often show overexpression of prostate-specific membrane antigen (PSMA). In prostate cancer, PSMA-ligands labeled with ⁶⁸Ga or ¹⁷⁷Lu are used for imaging and therapy, respectively. Primary aim of this study in R/M ACC and SDC patients was to systematically investigate ⁶⁸Ga-PSMA-uptake by PET/CT imaging to determine if PSMA radionuclide therapy could be a treatment option. Methods: In a prospective phase II study, PET/CT imaging was performed 1 h post injection of ⁶⁸Ga-PSMA-HBED-CC in 15 ACC patients and 10 SDC patients. Maximum standardiz

SUBMITTER: van Boxtel W 

PROVIDER: S-EPMC7019174 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature