Expression of Taste Receptor 2 Subtypes in Human Testis and Sperm.

ABSTRACT: Taste receptors (TASRs) are expressed not only in the oral cavity but also throughout the body, thus suggesting that they may play different roles in organ systems beyond the tongue. Recent studies showed the expression of several TASRs in mammalian testis and sperm, indicating an involvement of these receptors in male gametogenesis and fertility. This notion is supported by an impaired reproductive phenotype of mouse carrying targeted deletion of taste receptor genes, as well as by a significant correlation between human semen parameters and specific polymorphisms of taste receptor genes. To better understand the biological and thus clinical significance of these receptors for human reproduction, we analyzed the expression of several members of the TAS2Rs family of bitter receptors in hum

SUBMITTER: Governini L 

PROVIDER: S-EPMC7019805 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature