Stroke Prophylaxis in Patients with Atrial Fibrillation and End-Stage Renal Disease.

ABSTRACT: Atrial fibrillation (AF) is an important comorbidity in patients with end-stage renal disease (ESRD) undergoing dialysis that portends increased health care utilization, morbidity, and mortality in this already high-risk population. Patients with ESRD have a particularly high stroke risk, which is further compounded by AF. However, the role of anticoagulation for stroke prophylaxis in ESRD and AF is debated. The ESRD population presents a unique challenge because of the combination of elevated stroke and bleeding risks. Warfarin has been traditionally used in this population, but it is associated with significant risks of minor and major bleeding, particularly intracranial, thus leading many clinicians to forgo anticoagulation altogether. When anticoagulation is prescribed, rates of adhere

SUBMITTER: van Zyl M 

PROVIDER: S-EPMC7019832 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature