A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis.

ABSTRACT: Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and NRF2 genes have been associated with various lung disorders. To test whether specific NRF2 and/or AOE gene SNPs in children with RSV lower respiratory tract infection were associated with disease severity, one hundred and forty one children <24 month of age with bronchiolitis were assessed for seven AOE and two NRF2 SNPs, and data were correlated with disease severity, which was determined by need of oxygen supplementation and intensive care support. One SNP in the promoter region of the catala

SUBMITTER: Chambliss JM 

PROVIDER: S-EPMC7019864 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature