Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart.

ABSTRACT: Heart diseases are a leading cause of death. While the link between early exposure to nutritional excess and heart disease risk is clear, the molecular mechanisms involved are poorly understood. In the developmental programming field, increasing evidence is pointing out the critical role of epigenetic mechanisms. Among them, polycomb repressive complex 2 (PRC2) and DNA methylation play a critical role in heart development and pathogenesis. In this context, we aimed at evaluating the role of these epigenetic marks in the long-term cardiac alterations induced by early dietary challenge. Using a model of rats exposed to maternal high-fat diet during gestation and lactation, we evaluated cardiac alterations at adulthood. Expression levels of PRC2 components, its histone marks di- and trimethyl

SUBMITTER: Blin G 

PROVIDER: S-EPMC7019950 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature