Prophylactic Hepatitis E Vaccines: Antigenic Analysis and Serological Evaluation.

ABSTRACT: Hepatitis E virus (HEV) infection causes sporadic outbreaks of acute hepatitis worldwide. HEV was previously considered to be restricted to resource-limited countries with poor sanitary conditions, but increasing evidence implies that HEV is also a public health problem in developed countries and regions. Fortunately, several vaccine candidates based on virus-like particles (VLPs) have progressed into the clinical development stage, and one of them has been approved in China. This review provides an overview of the current HEV vaccine pipeline and future development with the emphasis on defining the critical quality attributes for the well-characterized vaccines. The presence of clinically relevant epitopes on the VLP surface is critical for eliciting functional antibodies against HEV infe

SUBMITTER: Li Y 

PROVIDER: S-EPMC7020013 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature