Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells.

ABSTRACT: Cancer cell-matrix interactions have been shown to enhance cancer cell survival via the activation of pro-survival signaling pathways. These pathways are initiated at the site of interaction, i.e., integrins, and thus, their inhibition has been the target of therapeutic strategies. Individual roles for fibronectin-binding integrin subtypes α_vβ₃ and α₅β₁ have been shown for various cellular processes; however, a systematic comparison of their function in adhesion-dependent chemoresistance is lacking. Here, we utilize integrin subtype-specific peptidomimetics for α_vβ₃ and α₅β₁, both as blocking agents on fibronectin-coated surfaces and as surface-immobilized adhesion sites, in order to parse out their rol

SUBMITTER: Young JL 

PROVIDER: S-EPMC7020138 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature