Electrochemical Detection of Tumor-Derived Extracellular Vesicles on Nanointerdigitated Electrodes.

ABSTRACT: Tumor-derived extracellular vesicles (tdEVs) are attracting much attention due to their essential function in intercellular communication and their potential as cancer biomarkers. Although tdEVs are significantly more abundant in blood than other cancer biomarkers, their concentration compared to other blood components remains relatively low. Moreover, the presence of particles in blood with a similar size as that of tdEVs makes their selective and sensitive detection further challenging. Therefore, highly sensitive and specific biosensors are required for unambiguous tdEV detection in complex biological environments, especially for decentralized point-of-care analysis. Here, we report an electrochemical sensing scheme for tdEV detection, with two-level selectivity provided by a sandwich i

SUBMITTER: Mathew DG 

PROVIDER: S-EPMC7020140 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature