THBS1 Is a Novel Serum Prognostic Factors of Acute Myeloid Leukemia.

ABSTRACT: Dysregulation of cytokines and growth factors is a general feature of tumor microenvironment, and unraveling the expression spectrum of cytokine and growth factor in niche is of utmost importance. Here, we evaluated cytokine profiling of bone marrow serum samples in AML patients and healthy controls. Protein expression profiling of serum from nine AML patients and five healthy controls was obtained using a biotinylated antibody chip. A total of 507 cytokines and growth factors were analyzed. Compared with healthy people, AML patients expressed 31 signature proteins, among which, 27 were significantly higher expressed and 4 proteins were lower. When patients were divided into favorable and poor prognosis, 12 signature proteins were significantly differentially expressed between these two gr

SUBMITTER: Zhu L 

PROVIDER: S-EPMC7020255 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature