Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction.

ABSTRACT:

Background

Septoplasty (surgery to straighten a deviation in the nasal septum) is a frequently performed operation worldwide, with approximately 250,000 performed annually in the US and 22,000 in the UK. Most septoplasties aim to improve diurnal and nocturnal nasal obstruction. The evidence base for septoplasty clinical effectiveness is hitherto very limited.

Aims

To establish, and inform guidance for, the best management strategy for individuals with nasal obstruction associated with a deviated septum.

Methods/design

A multicentre, mixed-methods, open label, randomised controlled trial of septoplasty versus medical management for adults with a deviated septum and a reduced nasal airway. Eligible patients will have septal deflection visible at nasendoscopy and a nasal

SUBMITTER: Rennie KJ 

PROVIDER: S-EPMC7020359 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature