EGFR modulates complement activation in head and neck squamous cell carcinoma.

ABSTRACT: BACKGROUND:The epidermal growth factor receptor (EGFR) is pivotal for growth of epithelial cells and is overexpressed in several epithelial cancers like head and neck squamous cell carcinoma (HNSCC). EGFR signalling is also involved in diverse innate immune functions in epithelia. We previously found a role for EGFR in modulating the complement system in skin, this prompted an investigation into EGFR role in complement modulation in HNSCC. METHODS:We used patient derived HNSCC cell lines with varying sensitivities to EGFR inhibitors, and generated EGFR inhibition resistant cell lines to study the role of EGFR in modulating complement in HNSCC. RESULTS:We found that HNSCC cell lines activate the complement system when incubated with human serum. This complement activation was increased in c

SUBMITTER: Abu-Humaidan AHA 

PROVIDER: S-EPMC7020369 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature