Venomics and Cellular Toxicity of Thai Pit Vipers (Trimeresurus macrops and T. hageni).

ABSTRACT: The two venomous pit vipers, Trimeresurus macrops and T. hageni, are distributed throughout Thailand, although their abundance varies among different areas. No species-specific antivenom is available for their bite victims, and the only recorded treatment method is a horse antivenom raised against T. albolabris crude venom. To facilitate assessment of the cross-reactivity of heterologous antivenoms, protein profiles of T. macrops and T. hageni venoms were explored using mass-spectrometry-based proteomics. The results show that 185 and 216 proteins were identified from T. macrops and T. hageni venoms, respectively. Two major protein components in T. macrops and T. hageni venoms were snake venom serine protease and metalloprotein

SUBMITTER: Kumkate S 

PROVIDER: S-EPMC7020458 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature