A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.

ABSTRACT:

Background

End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation.

Results

Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4⁺ (living:258 cells/μl vs. deceased:101 cells/μl, p < 

SUBMITTER: Betjes MGH 

PROVIDER: S-EPMC7020578 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature