Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials.

ABSTRACT: BACKGROUND:Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug in patients with co-morbidities. The aim of the study is to systematically examine the side effect profile of colchicine in controlled clinical trials across all published indications. METHODS:A systematic review was conducted in accordance with PRISMA methodology. The Cochrane Library, MEDLINE and EMBASE were searched for double-blind controlled trials of oral colchicine in adult patients that reported adverse event data. Meta-analyses were used to determine the relative risk (RR) of adverse events in colchicine users compared to comparator groups. RESULTS:A total of 4915

SUBMITTER: Stewart S 

PROVIDER: S-EPMC7020579 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature