Polymorphism of TPH2 Gene rs120074175 Is Not Associated with Risk Factors of Schizophrenia.

ABSTRACT:

Context

Polymorphism on tryptophan hydroxylase 2 (TPH2) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Reduced serotonin in the brain can cause dopamine release to occur continuously. Excess dopamine in the brain may cause positive symptom of schizophrenia.

Aim

The aim of this study was to investigate the genotype distribution of TPH2 rs120074175 gene on patients with schizophrenia at Prof. Dr. Soerojo Magelang Psychiatric Hospital, Indonesia, and the relationship between the genetic polymorphism of the TPH2 rs120074175 gene against risk factors of schizophrenia.

Settings and design

This was a cross-sectional study.

Materials and methods

The method used was amplification refractory m

SUBMITTER: Laksono JP 

PROVIDER: S-EPMC7020838 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature