COPDGene^® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need for an expanded definition of COPD that is linked to physiologic, structural (computed tomography [CT]) and clinical evidence of disease. Using data from the COPD Genetic Epidemiology study (COPDGene^®), we hypothesized that an integrated approach that includes environmental exposure, clinical symptoms, chest CT imaging and spirometry better defines disease and captures the likeli

SUBMITTER: Lowe KE 

PROVIDER: S-EPMC7020846 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature