The Association Between Sortilin and Inflammation in Patients with Coronary Heart Disease.

ABSTRACT:

Purpose

Inflammation is a key contributor to coronary heart disease (CHD). Sortilin is a sorting receptor and has been identified as a critical regulator of inflammatory response. Therefore, our study aimed to determine the link between circulating sortilin levels, proinflammatory cytokine levels, and the occurrence of CHD.

Patients and methods

Our study included 227 CHD patients and 101 matched healthy individuals. Circulating serum levels of sortilin and proinflammatory cytokines, including IL-1β, IL-6 and TNF-α, were assessed by a double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). Linear regression and correlation analyses were used to estimate the associations between sortilin and proinflammatory cytokines. Moreover, six single-nucleotide polymorphis

SUBMITTER: Han W 

PROVIDER: S-EPMC7020934 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature