Human 3D cellular model of hypoxic brain injury of prematurity.

ABSTRACT: Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates^1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called encephalopathy of prematurity³. Over 80% of infants born before post-conception week 25 have moderate-to-severe long-term neurodevelopmental impairments⁴. The susceptible cell types in the cerebral cortex and the molecular mechanisms underlying associated gray-matter defects in premature infants remain unknown. Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen deprivation on corticogenesis. We i

SUBMITTER: Pasca AM 

PROVIDER: S-EPMC7020938 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature