S1PR1-Associated Molecular Signature Predicts Survival in Patients with Sepsis.

ABSTRACT:

Background

Sepsis is a potentially life-threatening complication of an underlying infection that quickly triggers tissue damage in multiple organ systems. To date, there are no established useful prognostic biomarkers for sepsis survival prediction. Sphingosine-1-phosphate (S1P) and its receptor S1P receptor 1 (S1PR1) are potential therapeutic targets and biomarkers for sepsis, as both are active regulators of sepsis-relevant signaling events. However, the identification of an S1PR1-related gene signature for prediction of survival in sepsis patients has yet to be identified. This study aims to find S1PR1-associated biomarkers which could predict the survival of patients with sepsis using gene expression profiles of peripheral blood to be used as potential prognostic and diagnostic

SUBMITTER: Feng A 

PROVIDER: S-EPMC7020939 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature