Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.

ABSTRACT:

Background

Pretreatment HIV drug resistance (HIVDR) to NNRTIs has consistently increased in Mexico City during the last decade.

Objectives

To infer the HIV genetic transmission network in Mexico City to describe the dynamics of the local HIV epidemic and spread of HIVDR.

Patients and methods

HIV pol sequences were obtained by next-generation sequencing from 2447 individuals before initiation of ART at the largest HIV clinic in Mexico City (April 2016 to June 2018). Pretreatment HIVDR was estimated using the Stanford algorithm at a Sanger-like threshold (≥20%). Genetic networks were inferred with HIV-TRACE, establishing putative transmission links with genetic distances <1.5%. We examined demographic associations among linked individuals with shared drug resistance mut

SUBMITTER: Matias-Florentino M 

PROVIDER: S-EPMC7021100 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature