Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery.

ABSTRACT:

Background

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt the thyroid function. But epidemiological evidence on the association between PFAS and thyroid hormone (TH) levels in cord blood is scarce and controversial. We aimed to examine the association between cord blood PFAS concentrations and TH levels in prelabor caesarean deliveries.

Methods

We measured ten PFAS and three THs in cord blood in 568 prelabor caesarean deliveries. The associations between PFAS and TH levels were examined using multiple linear regression model and sparse partial least squares (SPLS) regression model.

Results

In SPLS analyses, thyroid stimulating hormone (TSH) level decreased with increasing concentrations of perfluorooctane sulfonate (PFOS, β = -0.012

SUBMITTER: Aimuzi R 

PROVIDER: S-EPMC7021220 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature