Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity.

ABSTRACT:

Objectives

The comorbidity of HIV infection and alcoholism (ALC) is prevalent. Wernicke's encephalopathy, a neurological disorder resulting from thiamine depletion, has been generally associated with alcoholism but has also been reported in HIV infection. This study examined whether subclinical Wernicke's encephalopathy signs could contribute to the heterogeneity of cognitive and motor deficits observed in individuals with both disease conditions (HIV+ALC).

Design

Sixty-one HIV+ALC individuals and 59 controls were assessed on attention and working memory, production, immediate and delayed episodic memory, visuospatial abilities, and upper limb motor function.

Methods

Using Caine criteria (dietary deficiency, oculomotor abnormality, cerebellar dysfunction, and altered

SUBMITTER: Le Berre AP 

PROVIDER: S-EPMC7021228 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature