A three-year whole genome sequencing perspective of Enterococcus faecium sepsis in Australia.

ABSTRACT:

Background

Over the last three decades, hospital adapted clonal complex (CC) 17 strains of Enterococcus faecium have acquired and exchanged antimicrobial resistance genes leading to the widespread resistance to clinically important antimicrobials globally. In Australia, a high prevalence of vancomycin resistance has been reported in E. faecium in the last decade.

Methods

In this study, we determined the phylogenetic relationship and genetic characteristics of E. faecium collected from hospitalized patients with blood stream infections throughout Australia from 2015 to 2017 using high throughput molecular techniques.

Results

Using single nucleotide polymorphism based phylogenetic inference, three distinct clusters of isolates were observed with additional sub-clusterin

SUBMITTER: Lee T 

PROVIDER: S-EPMC7021281 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature