Disease burden and seasonal impact of improving rotavirus vaccine coverage in the United States: A modeling study.

ABSTRACT:

Background

Prior to vaccine introduction in 2006, rotavirus was the leading cause of severe diarrhea in children under five years of age in the U.S. Vaccination of infants has led to major reductions in disease burden, a shift in the seasonal peak and the emergence of a biennial pattern of disease. However, rotavirus vaccine coverage has remained relatively low (70-75%) compared to other infant immunizations in the U.S. Part of the reason for this lower coverage is that children whose care is provided by family practitioners (FP) have considerably lower probability of being vaccinated compared to those seen be pediatricians (PE). We used a dynamic transmission model to assess the impact of improving rotavirus vaccine coverage by FP and/or PE on rotavirus gastroenteritis (RVGE) inci

SUBMITTER: Ai CE 

PROVIDER: S-EPMC7021296 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature