Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.

ABSTRACT:

Background

Zika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g. dengue virus) or flavivirus vaccinations. Since pre-existing cross-reactive immunity can potentially modulate antibody responses to Zika virus infection and may affect the outcome of disease, we analyzed fine-specificity as well as virus-neutralizing and infection-enhancing activities of antibodies induced by a primary Zika virus infection in flavivirus-naïve as well as yellow fever- and/or tick-borne encephalitis-vaccinated individuals.

Methodology

Antibodies in sera from convalescent Zika patients with and without vaccine-induced immunity

SUBMITTER: Malafa S 

PROVIDER: S-EPMC7021315 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature