Composite metric R₂  - R_1ρ (1/T₂  - 1/T_1ρ ) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up.

ABSTRACT: This study looked to investigate a new quantitative metric, R₂  - R_1ρ (1/T₂  - 1/T_1ρ ), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T_1ρ /T₂ protocol to calculate R_1ρ (1/T_1ρ ) and R₂ (1/T₂ ) values at baseline and 6 months after reconstructive surgery. Non-rigid registration was applied to align images onto a template, allowing VBR to determine VBR rate differences and explore cross-sectional and longitudi

SUBMITTER: Russell C 

PROVIDER: S-EPMC7021321 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature