Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model.

ABSTRACT: During angiogenesis, new blood vessels sprout and grow from existing ones. This process plays a crucial role in organ development and repair, in wound healing and in numerous pathological processes such as cancer progression or diabetes. Here, we present a mathematical model of early stage angiogenesis that permits exploration of the relative importance of mechanical, chemical and cellular cues. Endothelial cells proliferate and move over an extracellular matrix by following external gradients of Vessel Endothelial Growth Factor, adhesion and stiffness, which are incorporated to a Cellular Potts model with a finite element description of elasticity. The dynamics of Notch signaling involving Delta-4 and Jagged-1 ligands determines tip cell selection and vessel branching. Through their produ

SUBMITTER: Vega R 

PROVIDER: S-EPMC7021322 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature