Primary human chondrocytes respond to compression with phosphoproteomic signatures that include microtubule activation.

ABSTRACT: Chondrocytes are responsible for maintaining the cartilage that helps joints bear load and move smoothly. These cells typically respond to physiological compression with pathways consistent with matrix synthesis, and chondrocyte mechanotransduction is essential for homeostasis. In osteoarthritis (OA), chondrocyte mechanotransduction appears to be dysregulated, yet the mechanisms remain poorly understood. The objective of this study is to document the phosphoproteomic responses of primary osteoarthritic chondrocytes to physiological sinusoidal compression. We show that OA chondrocytes respond to physiological compression by first activating proteins consistent with cytoskeletal remodeling and decreased transcription, and then later activating proteins for transcription. These results show t

SUBMITTER: Zignego DL 

PROVIDER: S-EPMC7021325 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature