Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is a major public health challenge given its high global prevalence and associated risks of cardiovascular disease and progression to end stage renal disease. Although it is known that numerous metabolic changes occur in CKD patients, identifying novel metabolite associations with kidney function may enhance our understanding of the physiologic pathways relating to CKD.

Objectives

The objective of this study was to elucidate novel metabolite associations with kidney function among participants of two community-based cohorts with carefully ascertained metabolomics, kidney function, and covariate data.

Methods

Untargeted ultrahigh-performance liquid chromatography-tandem mass spectrometry was used to detect and quantify blood me

SUBMITTER: Nierenberg JL 

PROVIDER: S-EPMC7021455 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature