No association between cortical lesions and leptomeningeal enhancement on 7-Tesla MRI in multiple sclerosis.

ABSTRACT:

Background

Autopsy data suggest a causative link between meningeal inflammation and cortical lesions (CLs) in multiple sclerosis (MS).

Objective

To use leptomeningeal enhancement (LME) and CLs on 7-Tesla (7T) magnetic resonance imaging (MRI) to investigate associations between meningeal inflammation and cortical pathology.

Methods

Forty-one participants with MS underwent 7T MRI of the brain. CLs and foci of LME were quantified.

Results

All MS participants had CLs; 27 (65.8%) had >1 focus of LME. Except for hippocampal CL count (ρ = 0.32 with spread/fill-sulcal pattern LME, p = 0.042), no significant correlations were seen between LME and CLs. Mean cortical thickness correlated with the number of LME foci (ρ = -0.43, p = 0.005). Participants with r

SUBMITTER: Ighani M 

PROVIDER: S-EPMC7021560 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature