Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism.

ABSTRACT: Beta-adrenergic antagonism (e.g. propranolol) has been associated with cognitive/behavioral benefits following stress-induced impairments and for some cognitive/behavioral domains in individuals with autism spectrum disorder. In this preliminary investigation, we examined whether the benefits of propranolol are associated with functional properties in the brain. Adolescents/adults (mean age = 22.54 years) with (n = 13) and without autism spectrum disorder (n = 13) attended three sessions in which propranolol, nadolol (beta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo was administered before a semantic fluency task during functional magnetic resonance imaging. Autonomic nervous system measures and functional connectivity between language/assoc

SUBMITTER: Hegarty JP 

PROVIDER: S-EPMC7021567 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature