Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making.

ABSTRACT: Converging evidence from studies with animals and humans have implicated separate regions of the medial prefrontal cortex (mPFC) corresponding to the anterior cingulate cortex (ACC), in mediating different aspects of reward-related decisions involving uncertainty or risk. However, the dissociable contributions of subregions of the ACC remain unclear, as discrepancies exist between human neuroimaging findings and preclinical rodent studies. To clarify how ventral vs. dorsal regions of the mPFC contribute to risk/reward decision making, the present study assessed the effects of inactivation of different subregions on performance of a "Blackjack task" that measured cue-guided decision making and shares similarities with paradigms used with humans. Male, Long-Evans rats were well-trained to ch

SUBMITTER: van Holstein M 

PROVIDER: S-EPMC7021677 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature