Ontology highlight
ABSTRACT:
SUBMITTER: Liao Y
PROVIDER: S-EPMC7021685 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200214 1
Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STEAP4. IL-17-induced elevated intracellular copper level leads to the activation of an E3-ligase, XIAP, which potentiates IL-17-induced NFκB activation and suppresses the caspase 3 activity. Importantly ...[more]