Renal sinus fat and renal hemodynamics: a cross-sectional analysis.

ABSTRACT:

Objectives

Increased renal sinus fat (RSF) is associated with hypertension and chronic kidney disease, but underlying mechanisms are incompletely understood. We evaluated relations between RSF and gold-standard measures of renal hemodynamics in type 2 diabetes (T2D) patients.

Methods

Fifty-one T2D patients [age 63 ± 7 years; BMI 31 (28-34) kg/m²; GFR 83 ± 16 mL/min/1.73 m²] underwent MRI-scanning to quantify RSF volume, and subcutaneous and visceral adipose tissue compartments (SAT and VAT, respectively). GFR and effective renal plasma flow (ERPF) were determined by inulin and PAH clearances, respectively. Effective renal vascular resistance (ERVR) was calculated.

Results

RSF correlated negatively with GFR (r = - 0.38; p = 0.006) and ERPF (r = - 

SUBMITTER: Spit KA 

PROVIDER: S-EPMC7021744 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature