Aluminum and aluminum oxide nanomaterials uptake after oral exposure - a comparative study.

ABSTRACT: The knowledge about a potential in vivo uptake and subsequent toxicological effects of aluminum (Al), especially in the nanoparticulate form, is still limited. This paper focuses on a three day oral gavage study with three different Al species in Sprague Dawley rats. The Al amount was investigated in major organs in order to determine the oral bioavailability and distribution. Al-containing nanoparticles (NMs composed of Al⁰ and aluminum oxide (Al₂O₃)) were administered at three different concentrations and soluble aluminum chloride (AlCl₃·6H₂O) was used as a reference control at one concentration. A microwave assisted acid digestion approach followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis was developed to an

SUBMITTER: Krause BC 

PROVIDER: S-EPMC7021764 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature