Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.

ABSTRACT: Idiopathic inflammatory myopathies cause progressive muscle weakness and degeneration. Since high-dose glucocorticoids might not lead to full recovery of muscle function, physical exercise is also an important intervention, but some exercises exacerbate chronic inflammation and muscle fibrosis. It is unknown how physical exercise can have both beneficial and detrimental effects in chronic myopathy. Here we show that senescence of fibro-adipogenic progenitors (FAPs) in response to exercise-induced muscle damage is needed to establish a state of regenerative inflammation that induces muscle regeneration. In chronic inflammatory myopathy model mice, exercise does not promote FAP senescence or resistance against tumor necrosis factor-mediated apoptosis. Pro-senescent intervention combining exe

SUBMITTER: Saito Y 

PROVIDER: S-EPMC7021787 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature