Orbitofrontal cortex is selectively activated in a primate model of attentional bias to cocaine cues.

ABSTRACT: Attentional bias to drug-associated cues correlates with extent of current use, and risk of relapse among those attempting abstinence. Electroencephalogram (EEG) and functional imaging measures in clinical studies have previously investigated the neural basis of attentional bias, but the lack of animal models precluded investigation at the single-unit level. To complement results obtained from clinical studies, we have employed a non-human primate model of attentional bias to cocaine cues while simultaneously recording single-unit activity in cortical and striatal regions implicated in reward processing. Rhesus macaques conditioned to associate particular colors with cocaine or water reward performed an attentional bias task, in which those colors served as irrelevant distractors. Concurre

SUBMITTER: Baeg E 

PROVIDER: S-EPMC7021823 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature