Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics.

ABSTRACT: Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly minia

SUBMITTER: Burton A 

PROVIDER: S-EPMC7022161 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature