A qualitative solution with quantitative potential for the mouse hippocampal cortex flatmap problem.

ABSTRACT: The hippocampal formation (HPF) is a focus of intense experimental investigation, particularly because of its roles in conscious memory consolidation, spatial navigation, emotion, and motivated behaviors. However, the HPF has a complex three-dimensional geometry resulting from extreme curvature of its layers, and this presents a challenge for investigators seeking to decipher hippocampal structure and function at cellular and molecular scales (neuronal circuitry, gene expression, and other properties). Previously, this problem was solved qualitatively for the rat by constructing a physical surface model of the HPF based on histological sections, and then deriving from the model a flatmap. Its usefulness is exemplified by previous studies that used it to display topological relationships be

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC7022173 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature